Janeway’s Immunobiology, 9th Edition

ISBN: 9780815345510

The definitive text—completely updated and revised.

Janeway’s Immunobiology is a textbook for students studying immunology at the undergraduate, graduate, and medical school levels. As an introductory text, students will appreciate the book’s clear writing and informative illustrations, while advanced students and working immunologists will value its comprehensive scope and depth. Janeway’s Immunobiology presents immunology from a consistent point of view throughout-that of the host’s interaction with an environment full of microbes and pathogens.

The Ninth Edition has been thoroughly revised bringing the content up-to-date with significant developments in the field, especially on the topic of innate immunity, and improving the presentation of topics across chapters for better continuity.

Features

  • A consistent viewpoint promotes understanding: This text presents the immune system from the point of view of the host’s interaction with an environment full of microbes and pathogens. New for the Ninth Edition, the text is now organised around the concept of modular immune responses, combining innate and adaptive immunity into effector modules and explaining the integration of the innate and adaptive immune response.
  • Updated to reflect the latest research advances: The pace of discovery in immunology moves fast. New or expanded coverage includes: the latest developments on innate lymphoid cells and innate sensing mechanisms, including cyclic GMP-AMP synthase (cGAS) and activation of the STING pathway, an in-depth handling of follicular helper T cells and their role in B-cell class switching and affinity maturation, cytoskeletal reorganisation and integrin activation in antigen receptor signaling, expanded coverage on Akt and mTOR signaling, and more.
  • Tools to assess understanding: End-of-chapter questions have been completely revised and include a variety of question types to help students review important concepts. Additionally, the test bank, written by Leslie Berg (University of Massachusetts Medical School), features a comprehensive set of questions to assess student understanding.
Kenneth M. Murphy

Casey Weaver

Part I: An introduction to immunobiology and innate immunity
Chapter 1. Basic concepts in immunology
Chapter 2. Innate immunity: The first lines of defense
Chapter 3. The induced responses of innate immunity

Part II: The recognition of antigen
Chapter 4. Antigen recognition by B-cell and T-cell receptors
Chapter 5. The generation of lymphocyte antigen receptors
Chapter 6. Antigen presentation to T lymphocytes

Part III: The development of mature lymphocyte receptor repertoires
Chapter 7. Lymphocyte receptor signaling
Chapter 8. The development of B and T lymphocytes

Part IV: The adaptive immune response
Chapter 9. T-cell-mediated immunity
Chapter 10. The humoral immune response
Chapter 11. Integrated dynamics of innate and adaptive immunity
Chapter 12. The mucosal immune system

Part V: The immune system in health and disease
Chapter 13. Failures of host defense mechanisms
Chapter 14. Allergy and allergic diseases
Chapter 15. Autoimmunity and transplantation
Chapter 16. Manipulation of the immune response

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Textbook: 9780815345510