Organic Chemistry, 12th Edition

ISBN: 9781118875766

The 12th edition of Organic Chemistry continues Solomons/Fryhle/Snyder’s tradition of excellence in teaching and preparing you for success in the organic classroom and beyond.


A central theme of the authors’ approach to organic chemistry is to emphasize the relationship between structure and reactivity. To accomplish this, the content is organized in a way that combines the most useful features of a functional group approach with one largely based on reaction mechanisms. The authors’ philosophy is to emphasize mechanisms and their common aspects as often as possible, and at the same time, use the unifying features of functional groups as the basis for most chapters.

WileyPLUS with ORION for Organic Chemistry 12e also features new conceptual practice exercises and support for students including interactive concept map exercises, interactive summary of reactions exercises, interactive mechanism review exercises, and video walkthroughs of key mechanisms by the authors. In response to market feedback, the authors have improved the current presentation of the chemistry of benzene rings by moving Chapter 21, Phenols and Aryl Halides after Chapter 15, Reactions of Aromatic Compounds. Other 12e revisions include new end of chapter problems that requires the student to use synthesis methods across chapters and the New Transition Metal Chemistry chapter.


  • Mechanism of the Reaction boxes throughout the book explain in detail everything a student needs to know about a reaction mechanism.
  • Coverage of topics in green chemistry, nanotechnology, and biochemistry to introduce students to exciting and important frontiers of organic chemistry.
  • The inclusion of Chemistry Of boxes present examples of biological and real-world chemistry that help students relate organic chemistry to the world.
  • Early introduction of infrared spectroscopy (Ch. 2) to give students evidence for functional groups and structure, and supports their use of instrumentation in laboratory classes. Tools such as Concept Maps, Synthetic Connections, and Mechanism Reviews summarize key information for students at the end of chapters.
T. W. Graham Solomons
University of South Florida

Craig B. Fryhle
Lutheran University

Scott A. Snyder
Columbia University

1. The Basics Bonding and Molecular Structure
2. Families of Carbon Compounds Functional Groups, Intermolecular Forces, and Infrared (IR) Spectroscopy
3. Acids and Bases An Introduction to Organic Reactions and Their Mechanisms
4. Nomenclature and Conformations of Alkanes and Cycloalkanes
5. Stereochemistry Chiral Molecules
6. Nucleophilic Reactions Properties and Substitution Reactions of Alkyl Halides
7. Alkenes and Alkynes I Properties and Synthesis. Elimination Reactions of Alkyl Halides
8. Alkenes and Alkynes II Addition Reactions
9. Nuclear Magnetic Resonance and Mass Spectrometry Tools for Structure Determination
10. Radical Reactions
11. Alcohols and Ethers Synthesis and Reactions
12. Alcohols from Carbonyl Compounds Oxidation–Reduction and Organometallic Compounds
13. Conjugated Unsaturated Systems
14. Aromatic Compounds
15. Reactions of Aromatic Compounds
16. Aldehydes and Ketones Nucleophilic Addition to the Carbonyl Group
17. Carboxylic Acids and Their Derivatives Nucleophilic Addition–Elimination at the Acyl Carbon
18. Reactions at the α Carbon of Carbonyl Compounds Enols and Enolates
19. Condensation and Conjugate Addition Reactions of Carbonyl Compounds More Chemistry of Enolates
20. Amines
21. Transition Metal Complexes Promoters of Key Bond-Forming Reactions
22. Carbohydrates
23. Lipids
24. Amino Acids and Proteins
25. Nucleic Acids and Protein Synthesis
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E-Text: 9781119233640
E-Text + WileyPLUS with ORION: 9781119368175
Binder Version: 9781119077251
Binder Version + WileyPLUS with ORION: 9781119238331
Text: 9781118875766
Text + WileyPLUS with ORION: 9781119077299